A distributed infrastructure for life-science information - Building a sustainable European infrastructure for biological information, supporting life science research and its translation to medicine, agriculture, bioindustries and society
From September 2015, ‘ELIXIR-EXCELERATE’ is facilitating the integration of Europe’s bioinformatics resources, supporting all sectors of life-science R&D. It will deliver excellence to ELIXIR’s users by fast-tracking the development and deployment of essential data services. EXCELERATE funding...
Coordinator: Niklas Bloomberg
Dynamics of human genome architecture in stable and transient gene expression changes
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output...
Coordinator: Miguel Beato
The Genomic study of Chronic Lymphocytic Leukaemia
The International Cancer Genome Consortium is an international effort to establish a comprehensive descriptionof genomic, transcriptomic and epigenomic changes in50 different tumor types and/or subtypes which are of clinical and societal importance across the globe. Spain’scontribution to the ICGC...
Coordinator: Elias Campo & Carlos López-Otín
Elucidating structural variation in primate genomes
The PRIMATE project aims to discover the extent of genome structural polymorphism within the great ape species by generating next-generation sequencing datasets at high coverage from multiple individuals of diverse species and subspecies, characterizing structural variants and validating them...
Coordinator: Tomàs Marquès-Bonet
Development of new statistical tools for improving the detection of population substructure at individual level with applications in humans
Detecting population substructure in Homo sapiens from the genetic diversity of the species is cumbersome given its evolutionary history and recent origin. Nevertheless, population substructure represents a serious threat when conducting GWAS and properly identifying its signature is essential for...
Coordinator: Oscar Lao
Exploration of non-random Somatic Mutations in Cancer Genomes
Cancer is a disease of the genome. Somatic mutations accumulate on top of the germline genome from many exogenous insults that we are constantly exposed to. If mutations are not removed or repaired they can result in progression to cancer disease. It is know that many of the insults we are exposed...
Coordinator: Ivo Gut

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