Boosting the Infrastructure for Omics Technologies
All omics technologies produce large volumes of data that require very specific processing and preparation for downstream interpretation. Going forward the major problems for all omics technologies is to provide efficient, robust and standardized methods for primary data handling and analysis. It...
Coordinator: Ivo Gut
Exploration of non-random Somatic Mutations in Cancer Genomes
Cancer is a disease of the genome. Somatic mutations accumulate on top of the germline genome from many exogenous insults that we are constantly exposed to. If mutations are not removed or repaired they can result in progression to cancer disease. It is know that many of the insults we are exposed...
Coordinator: Ivo Gut
Development of new statistical tools for improving the detection of population substructure at individual level with applications in humans
Detecting population substructure in Homo sapiens from the genetic diversity of the species is cumbersome given its evolutionary history and recent origin. Nevertheless, population substructure represents a serious threat when conducting GWAS and properly identifying its signature is essential for...
Coordinator: Oscar Lao
Multi-scale complex genomics
The European three-dimensional (3D) genomics project entitled “Multi-scale complex genomics” (MuG) is coordinated by Dr. Modesto Orozco, at the Institute for Research in Biomedicine (IRB Barcelona) and it will be conducted over three years with a budget of 3 million euros. The goal is to...
Coordinator: Modesto Orozco
Breast CAncer STratification - Understanding the determinants of risk and prognosis of molecular breast cancer subtypes. The aim of B-CAST is to identify women at moderate to high risk of breast cancer, the subtype of cancer that is most likely to develo
The B-CAST project (Breast CAncer STratification) is coordinated by the Netherlands Cancer Institute Antoni Van Leeuwenhoek and it will be conducted over five years (until September 2020). Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental...
Coordinator: Marjanka Schmidt
Dynamics of human genome architecture in stable and transient gene expression changes
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output...
Coordinator: Miguel Beato